The DFCAT model characterized observed MRI fluid volume and its dynamic changes from 275 to 46.5 mL in stomach (from 0 to 30 min) with mucus layer volume of 40 mL. The measured local GI concentration of phenol red ranged from 0.05 to 168 μg/mL (stomach), to 563 μg/mL (duodenum), to 202 μg/mL (proximal jejunum), and to 478 μg/mL (distal jejunum). The model was validated using GI local concentration of phenol red in human GI tract, which was directly measured by human GI intubation study after oral dosing of non-absorbable phenol red. The dynamic fluid compartment absorption and transit (DFCAT) model is proposed to estimate in vivo GI volume and GI fluid transport based on magnetic resonance imaging (MRI) quantified fluid volume. However, key questions regarding the local volume and its absorption, secretion, and transit remain unanswered. (GI) fluid volume and its dynamic change are integral to study drug disintegration, dissolution, transit, and absorption. 8 College of Pharmacy, The University of Michigan, North Campus Research Complex (NCRC), Room 3353, Building 520,1600 Huron Parkway, Ann Arbor, Michigan, 48109, USA. 7 College of Pharmacy, Tianjin Medical University, Tianjin, People's Republic of China.
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